Cerebrospinal fluid nitric oxide levels in childhood bacterial meningitis

Uysal G., Yüksel G., Sinav B., YÜKSEL S., UYSAL H.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, vol.31, no.5, pp.518-520, 1999 (SCI-Expanded) identifier identifier identifier


The role of nitric oxide (NO) in childhood bacterial meningitis was investigated by determining the levels of nitrate/nitrite, stable end products of NO metabolism, in cerebrospinal fluid (CSF). Eighteen children with bacterial meningitis and 18 as a control group were included in the study. Mean (+/- SD) CSF nitrate/nitrite levels were 27.6 +/- 26 mu mol/l in the bacterial meningitis group and 3.2 +/- 1.8 mu mol/l in the control group (p = 0.0005). We found no correlation between CSF nitrate/nitrite levels and CSF white blood cell count (r = 0.22), protein (r = 0.26) or tumour necrosis factor alpha (TNF-alpha) levels (r = 0.046), but a moderate negative correlation between CSF nitrate/nitrite and glucose levels (r = -0.46).