Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: An in vitro study

Yıldız, M.; Celik-Ozenci, ÇİLER; Akan, Selma; Akan, Ilhan; Sati, GÜLER; Demir, RAMAZAN; Savaş, Burhan; Ozben, TOMRİS; Samur, Mehmet; Özdoğan, M; Artaç, M.; Bozcuk, HAKAN

doi:10.1016/j.cellbi.2005.11.008

Zoledronic acid is synergic with vinblastine to induce apoptosis in a multidrug resistance protein-1 dependent way: An in vitro study

Atıf İçin Kopyala

Yıldız M., Celik-Ozenci C., Akan S., Akan I., Sati L., Demir R., ...Daha Fazla

CELL BIOLOGY INTERNATIONAL, cilt.30, sa.3, ss.278-282, 2006 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 30 Sayı: 3
Basım Tarihi: 2006
Doi Numarası: 10.1016/j.cellbi.2005.11.008
Dergi Adı: CELL BIOLOGY INTERNATIONAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.278-282
Anahtar Kelimeler: apoptosis, zoledronic acid, TUNEL, multidrug resistance, vinblastine, METASTASES, CANCER, TUMORS, CELLS
Akdeniz Üniversitesi Adresli: Evet

Özet

We have explored the action of zoledronic acid, which has an apoptotic effect and is used as an agent for treating skeletal metastases and osteoporosis, in the presence of vinblastine, and whether this effect is associated with MRP-1 (multidrug resistance protein-1) expression. HEK (human embryonic kidney) 293 cells were transfected to form the multidrug resistant cell line designated 293MRP (MRP-1 expressing HEK293 cells). Both lines were treated with varying concentrations of vinblastine and zoledronic acid. Apoptosis was determined by the TUNEL (deoxyuridine triphosphate nick end-labeling) method.