Copy For Citation
Olgar Y., Celen M. C., Yamasan B. E., Ozturk N., TURAN B., ÖZDEMİR S.
CELL CALCIUM, vol.67, pp.81-90, 2017 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
67
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Publication Date:
2017
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Doi Number:
10.1016/j.ceca.2017.09.002
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Journal Name:
CELL CALCIUM
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.81-90
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Keywords:
Cardiac hypertrophy, Rho kinases, Contractility, Calcium, Fasudil, Myocyte, CHANNEL RYANODINE RECEPTOR, INDUCED HEART-FAILURE, PROTEIN-KINASE, RAT-HEART, HYPERTENSIVE-RATS, FAILING HEARTS, CONTRACTILE, PHOSPHORYLATION, CLEAVAGE, MYOCYTES
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Akdeniz University Affiliated:
Yes
Abstract
Recent studies have implicated a relationship between RhoA/ROCK activity and defective Ca2+ homeostasis in hypertrophic hearts. This study investigated molecular mechanism underlying ROCK inhibition-mediated cardioprotection against pressure overload-induced cardiac hypertrophy, with a focus on Ca2+ homeostasis.