Exercise prevents high-fat diet-induced hyperalgesia in rats: an in vivo microdialysis study Exercício previne hiperalgesia induzida por dieta rica em gordura em ratos: um estudo de microdiálise in vivo
Arquivo Brasileiro de Medicina Veterinaria e Zootecnia, cilt.78, sa.3, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1590/1678-4162-13651
- Dergi Adı: Arquivo Brasileiro de Medicina Veterinaria e Zootecnia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
- Anahtar Kelimeler: Exercise training, gyrus cinguli, microdialysis, opioids, rats
- Akdeniz Üniversitesi Adresli: Evet
Özet
In this study, we investigated pain threshold and β-endorphin concentration in both sedentary and exercise trained rats under high fat diet induced obesity. Forty male Sprague-Dawley rats were assigned to one of four groups: sedentary control (C), exercise trained (T), high fat diet (HFD) and exercise trained under high fat diet (HFD-T). Exercise trained groups were subjected to 5 days / week for 8 weeks of motor driven treadmill exercise. HFD was induced as diet regimen containing 50% fat. Animals were placed individually on a hot plate at 55∘C and withdrawal latency for hind paw was recorded as pain threshold. Initial and final β-endorphin levels in plasma and microdialysate samples from anterior cingulate cortex (ACC) were measured. Animals in T and HFD-T groups had significantly higher exhaustion time compared to C and HFD groups. HFD group had lowest pain threshold latency compared to other groups. At plasma in HFD-T group and in ACC of HFD group had lowest β-endorphin concentrations. We concluded that exercise training restores the hyperalgesic response and partially β-endorphin concentration at ACC in HFD-induced obesity model of rats.