Apoptotic Functions of PDCD10/CCM3, the Gene Mutated in Cerebral Cavernous Malformation 3

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Chen L., Tanriover G., Yano H., Friedlander R., Louvi A., Gunel M.

STROKE, cilt.40, sa.4, ss.1474-1481, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1161/strokeaha.108.527135
  • Dergi Adı: STROKE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1474-1481
  • Anahtar Kelimeler: cerebral cavernous malformations, CCM3, PDCD10, apoptosis, p38, caspase-3, CCM3 MUTATIONS, CHROMOSOME 7Q, PROTEIN, KRIT1, PATHOGENESIS, ACTIVATION, EXPRESSION, PATHWAY, GROWTH, MORPHOGENESIS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background and Purpose-Mutations in the Programmed Cell Death 10 (PDCD10) gene cause amosomal dominant familial cerebral cavernous malformations (CCM3). To date, little is known about the function of this gene and its role in disease pathogenesis.