Apoptotic Functions of PDCD10/CCM3, the Gene Mutated in Cerebral Cavernous Malformation 3

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Chen L., Tanriover G., Yano H., Friedlander R., Louvi A., Gunel M.

STROKE, vol.40, no.4, pp.1474-1481, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2009
  • Doi Number: 10.1161/strokeaha.108.527135
  • Journal Name: STROKE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1474-1481
  • Keywords: cerebral cavernous malformations, CCM3, PDCD10, apoptosis, p38, caspase-3, CCM3 MUTATIONS, CHROMOSOME 7Q, PROTEIN, KRIT1, PATHOGENESIS, ACTIVATION, EXPRESSION, PATHWAY, GROWTH, MORPHOGENESIS
  • Akdeniz University Affiliated: Yes

Abstract

Background and Purpose-Mutations in the Programmed Cell Death 10 (PDCD10) gene cause amosomal dominant familial cerebral cavernous malformations (CCM3). To date, little is known about the function of this gene and its role in disease pathogenesis.