Presence of S100A8/Gr1-Positive Myeloid-Derived Suppressor Cells in Primary Tumors and Visceral Organs Invaded by Breast Carcinoma Cells
CLINICAL BREAST CANCER, vol.18, no.5, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 5
- Publication Date: 2018
- Doi Number: 10.1016/j.clbc.2018.03.013
- Journal Name: CLINICAL BREAST CANCER
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: Breast cancer, GR1, Immunohistochemistry, MDSC, S100A8/A9, S100 PROTEINS, CANCER, INFLAMMATION, LIVER, EXPRESSION, PATTERN, DIFFERENTIATION, CARCINOGENESIS, AGGRESSIVENESS, NEUTROPHILS
- Akdeniz University Affiliated: Yes
Abstract
In a study performed to determine S100A8/A9 and coexpression of Gr1 in metastatic breast carcinoma, we found that that tumor-derived factors may increase S100A8/A9-positive cells locally and systemically. We also showed that S100A8/A9 positive cells were increased in metastatic lesions. S100A8/A9-positive cells may be an appropriate milieu for the formation of metastasis and may be used to predict the metastatic potential of primary breast tumors.