Presence of S100A8/Gr1-Positive Myeloid-Derived Suppressor Cells in Primary Tumors and Visceral Organs Invaded by Breast Carcinoma Cells

Tanriover, GAMZE; EYINC, Mehmet; ALIYEV, Elnur; Dilmac, SAYRA; ERIN, Nurav

doi:10.1016/j.clbc.2018.03.013

Presence of S100A8/Gr1-Positive Myeloid-Derived Suppressor Cells in Primary Tumors and Visceral Organs Invaded by Breast Carcinoma Cells

Tanriover G., EYINC M. B., ALIYEV E., Dilmac S., ERIN N.

CLINICAL BREAST CANCER, cilt.18, sa.5, 2018 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 18 Sayı: 5
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.clbc.2018.03.013
Dergi Adı: CLINICAL BREAST CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Breast cancer, GR1, Immunohistochemistry, MDSC, S100A8/A9, S100 PROTEINS, CANCER, INFLAMMATION, LIVER, EXPRESSION, PATTERN, DIFFERENTIATION, CARCINOGENESIS, AGGRESSIVENESS, NEUTROPHILS
Akdeniz Üniversitesi Adresli: Evet

Özet

In a study performed to determine S100A8/A9 and coexpression of Gr1 in metastatic breast carcinoma, we found that that tumor-derived factors may increase S100A8/A9-positive cells locally and systemically. We also showed that S100A8/A9 positive cells were increased in metastatic lesions. S100A8/A9-positive cells may be an appropriate milieu for the formation of metastasis and may be used to predict the metastatic potential of primary breast tumors.