Activity of neutrophil NADPH oxidase in iron-deficient anemia

Kurtoglu E., Ugur A., Baltaci A., Mogolkoc R., Undar L.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.96, sa.1-3, ss.109-115, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96 Sayı: 1-3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1385/bter:96:1-3:109
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.109-115
  • Anahtar Kelimeler: iron-deficiency anemia, iron supplementation, neutrophil function, NADPH oxidase
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

This study was designed to measure the effects of iron supplementation on respiratory burst in iron-deficient anemia. The performance of neutrophils was evaluated by measuring the activity of NADPH oxidase in 18 patients with iron-deficient anemia before and after body iron stores are saturated. The activity of NADPH oxidase was significantly lower in pretreatment patients relative to controls (p<0.05). The activity increased after iron supplementation to levels that had no significant differences relative to controls.