Activity of neutrophil NADPH oxidase in iron-deficient anemia

Kurtoglu E., Ugur A., Baltaci A., Mogolkoc R., Undar L.

BIOLOGICAL TRACE ELEMENT RESEARCH, vol.96, no.1-3, pp.109-115, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 1-3
  • Publication Date: 2003
  • Doi Number: 10.1385/bter:96:1-3:109
  • Journal Name: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.109-115
  • Keywords: iron-deficiency anemia, iron supplementation, neutrophil function, NADPH oxidase
  • Akdeniz University Affiliated: No

Abstract

This study was designed to measure the effects of iron supplementation on respiratory burst in iron-deficient anemia. The performance of neutrophils was evaluated by measuring the activity of NADPH oxidase in 18 patients with iron-deficient anemia before and after body iron stores are saturated. The activity of NADPH oxidase was significantly lower in pretreatment patients relative to controls (p<0.05). The activity increased after iron supplementation to levels that had no significant differences relative to controls.