Human fetal placental endothelial cells have a mature arterial and a juvenile venous phenotype with adipogenic and osteogenic differentiation potential

Lang I., Schweizer A., Hiden U., Ghaffari-Tabrizi N., Hagendorfer G., Bilban M., ...More

DIFFERENTIATION, vol.76, no.10, pp.1031-1043, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 76 Issue: 10
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1432-0436.2008.00302.x
  • Journal Name: DIFFERENTIATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1031-1043
  • Keywords: placenta, arteries, veins, fetal endothelium, differentiation, SMOOTH-MUSCLE-CELLS, HUMAN TERM PLACENTA, STEM-CELLS, VASCULAR MORPHOGENESIS, MOLECULAR DISTINCTION, LYMPHATIC VESSEL, HETEROGENEITY, ANGIOGENESIS, EXPRESSION, PREGNANCY
  • Akdeniz University Affiliated: Yes

Abstract

Growing interest in the sources of origin of blood vessel related diseases has led to an increasing knowledge about the heterogeneity and plasticity of endothelial cells lining arteries and veins. So far, most of these studies were performed on animal models. Here, we hypothesized that the plasticity of human fetal endothelial cells depends on their vascular bed of origin i.e. vein or artery and further that the differences between arterial and venous endothelial cells would extend to phenotype and genotype.