Maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.33, sa.5, ss.861-868, 2020 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 5
- Basım Tarihi: 2020
- Doi Numarası: 10.1080/14767058.2019.1637409
- Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
- Sayfa Sayıları: ss.861-868
- Anahtar Kelimeler: Galectin-1, galectin-3, lectins, preterm birth, preterm prelabor rupture of membranes, PLACENTAL PROTEIN 13, PREMATURE RUPTURE, CHORIOAMNIONITIS, EXPRESSION, FAMILY, DELIVERY, LECTINS, MARKERS, GROWTH, TISSUE
- Akdeniz Üniversitesi Adresli: Evet
Özet
Objective: To investigate maternal serum galectin-1 and galectin-3 levels in pregnancies complicated with preterm prelabor rupture of membranes (PPROM) and to compare with pregnancies delivered at term. Materials and methods: In this cross-sectional study, 40 women with singleton pregnancies complicated with PPROM between 24 and 34 weeks of gestation were compared with gestational age-matched 40 pregnant women with no obstetrics complications, who delivered at term. The maternal serum galectin-1 and galectin-3 levels were measured. Results: Patients complicated with PPROM had significantly higher levels of galectin-1 (p = .001) and galectin-3 (p = .003) than the control group. Maternal serum galectin-3 levels were found significantly negatively correlated with the gestational age at delivery and birth weight. Conclusion: Maternal serum galectin-1 and galectin-3 levels were significantly higher in pregnancies complicated with PPROM. Galectin-1 and galectin-3, with their regulatory effects in key biological processes, may be both an initiating factor in the pathophysiology of PPROM, a marker in the prediction, and a target of preventing strategies of PPROM.