Bone mineral density in patients with familial Mediterranean fever

Yildirim K., Karatay S., Cetinkaya R., UZKESER H., ERDAL A., ÇAPOĞLU İ., ...More

RHEUMATOLOGY INTERNATIONAL, vol.30, no.3, pp.305-308, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1007/s00296-009-0950-3
  • Journal Name: RHEUMATOLOGY INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.305-308
  • Keywords: Familial Mediterranean fever, Bone mineral density, Osteoporosis, TUMOR-NECROSIS-FACTOR, ACUTE-PHASE RESPONSE, ANKYLOSING-SPONDYLITIS, RHEUMATOID-ARTHRITIS, BEHCETS-DISEASE, DIAGNOSIS, OSTEOPOROSIS, ALPHA, IL-6
  • Akdeniz University Affiliated: No

Abstract

This study was carried out to determine lumbar and femoral bone mineral density (BMD) in patients with familial Mediterranean fever (FMF), an autosomal-recessive disease characterized by recurrent episodes of peritonitis, pleuritis, and arthritis, which are usually associated with fever. In patients with FMF and control subjects, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured. BMD was determined at the lumbar spine (L1-4) and the femoral regions (neck and total) using dual energy X-ray absorptiometry. Twenty-eight FMF patients and 30 control subjects without a history of inflammatory disease participated in our study. The demographic variables, such as age, sex and body mass index were similar between patients and controls (P > 0.05). We found statistically significant difference in ESR and CRP between FMF patients and controls (P < 0.01, P < 0.05 respectively). There was statistically significant difference in lumbar spine, femoral neck, and total femur BMD between FMF patients and control groups (P < 0.001, P < 0.01, P < 0.01 respectively).Our study indicates that lumbar spine and femoral neck and total femur BMD in patients with FMF may be lower than in healthy subjects.