Akademik Veri Yönetim Sistemi
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.31, sa.4, ss.969-975, 2011 (SCI-Expanded)
Mast cells (MCs) are multifunctional cells. At present, MCs are known to play roles in many different physiologic and pathologic events such as bacterial infections, adaptive-innate immunity reactions, angiogenesis, tissue repair, hemostasis, postoperative adhesion formation, wound healing and inflammation processes, in addition to their roles in allergy-anaphylaxis. MCs also have important roles in pathogenesis of various surgical diseases (inflammatory bowel diseases, postoperative ileus, irritable bowel syndrome, hemorrhoid etc.) and many surgical cancer types. The opinion that providing MC stabilization could be a novel therapeutic approach for shortening postoperative ileus and that MC may have a role in viseral hypersensitivity and pain perception in Irritable Bowel Syndrome are only a few of the opinions suggested for MC. On the other hand, it is suggested that MC is a promising cell in novel cancer therapies. Data indicate that MCs may act as tumor inhibitors or promoters, probably depending on the environmental factors. We emphasize that MC plays a positive role in its relationship with tumor and it leads to tumor regression, rather than tumor growth, based on our in vitro study indicating its cytotoxicity against tumor cells in human myeloid leukemia and lymphoma, and our clinical study in which we did not detect any correlation between MC and angiogenesis in endometrial carcinoma. In this paper, we will discuss the important roles of MC that have been described in recent years in surgical diseases and in some surgical tumors.