First outbreak of vancomycin-resistant enterococci in a tertiary hospital in Turkey

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COLAK D., NAAS T., GUNSEREN F., Fortineau N., OGUNC D., Gultekin M., ...Daha Fazla

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, cilt.50, sa.3, ss.397-401, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 3
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1093/jac/dkf134
  • Dergi Adı: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.397-401
  • Anahtar Kelimeler: Enterococcus faecium, VRE, outbreak, VANA GLYCOPEPTIDE RESISTANCE, IDENTIFICATION, ELEMENTS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Twenty multidrug-resistant vancomycin-resistant Enterococcus faecium strains of the VanA phenotype were isolated over a 1 year period from five patients in the intensive care unit at the University Hospital of Antalya, Turkey. Molecular investigation showed that these strains belonged to five different pulsotypes and that the vanA gene was carried by a Tn1546-like transposon inserted onto a self-transferable plasmid of approximately 200 kb. One patient was infected by two different strains, suggesting horizontal gene transfer within that patient. This is the first documented outbreak of VRE in Turkey with concomitant spread of plasmid and strains.