Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia

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Altiok O., YASUMATSU R., BINGOL-KARAKOC G., RIESE R., STAHLMAN M., DWYER W., ...More

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol.173, no.3, pp.318-326, 2006 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 173 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1164/rccm.200503-425oc
  • Journal Name: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.318-326
  • Keywords: baboon, bronchopulmonary dysplasia, cathepsin, macrophage, protease, CHRONIC LUNG-DISEASE, MEDIATED HEPATOCYTE APOPTOSIS, NECROSIS-FACTOR-ALPHA, LOW-BIRTH-WEIGHT, CATHEPSIN-K, ALPHA-1-PROTEINASE INHIBITOR, ELASTIN DEPOSITION, PULMONARY-FUNCTION, PRETERM LAMBS, EXPRESSION
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: No

Abstract

Rationale: Bronchopulmonary dysplasia (BPD) continues to be a major morbidity in preterm infants. The lung pathology in BIRD is characterized by impaired alveolar and capillary development. An imbalance between proteases and protease inhibitors in association with changes in lung elastic fibers has been implicated in the pathogenesis of BIRD.