Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia

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Altiok O., YASUMATSU R., BINGOL-KARAKOC G., RIESE R., STAHLMAN M., DWYER W., ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.173, sa.3, ss.318-326, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 173 Sayı: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1164/rccm.200503-425oc
  • Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.318-326
  • Anahtar Kelimeler: baboon, bronchopulmonary dysplasia, cathepsin, macrophage, protease, CHRONIC LUNG-DISEASE, MEDIATED HEPATOCYTE APOPTOSIS, NECROSIS-FACTOR-ALPHA, LOW-BIRTH-WEIGHT, CATHEPSIN-K, ALPHA-1-PROTEINASE INHIBITOR, ELASTIN DEPOSITION, PULMONARY-FUNCTION, PRETERM LAMBS, EXPRESSION
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Rationale: Bronchopulmonary dysplasia (BPD) continues to be a major morbidity in preterm infants. The lung pathology in BIRD is characterized by impaired alveolar and capillary development. An imbalance between proteases and protease inhibitors in association with changes in lung elastic fibers has been implicated in the pathogenesis of BIRD.