Discovery by a proteomic approach of possible early biomarkers of drug-induced nephrotoxicity in medication-overuse headache
JOURNAL OF HEADACHE AND PAIN, vol.14, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 14
- Publication Date: 2013
- Doi Number: 10.1186/1129-2377-14-6
- Journal Name: JOURNAL OF HEADACHE AND PAIN
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: Medication-overuse headache, Proteomics, NSAIDs, Nephrotoxicity, SELDI-TOF-MS, Two-dimensional gel electrophoresis, ACID-BINDING PROTEIN, URINARY PROTEOMICS, BETA-2-MICROGLOBULIN, SERUM, COMBINATION, ALBUMIN, MARKER
- Open Archive Collection: AVESIS Open Access Collection
- Akdeniz University Affiliated: Yes
Abstract
Background: Medication-overuse headache (MOH) is a chronic headache condition that results from the overuse of analgesics drugs, triptans, or other antimigraine compounds. The epidemiology of drug-induced disorders suggests that medication overuse could lead to nephrotoxicity, particularly in chronic patients. The aim of this work was to confirm and extend the results obtained from a previous study, in which we analyzed the urinary proteome of 3 MOH patients groups: non-steroidal anti-inflammatory drugs (NSAIDs), triptans and mixtures abusers, in comparison with non-abusers individuals (controls).