The Short- and Long-term Effects of Estrogen Deficiency on Apoptosis in Musculoskeletal Tissues: An Experimental Animal Model Study

Aydin, Adem; Kenar, Halime; Atmaca, HALİL; Alici, Tugrul; GACAR, GÜLÇİN; Muezzinoglu, Umit; Karaoz, Erdal

The Short- and Long-term Effects of Estrogen Deficiency on Apoptosis in Musculoskeletal Tissues: An Experimental Animal Model Study

Aydin A., Kenar H., Atmaca H., Alici T., GACAR G., Muezzinoglu U. S., ...More

ARCHIVES OF IRANIAN MEDICINE, vol.16, no.5, pp.271-276, 2013 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 16 Issue: 5
Publication Date: 2013
Journal Name: ARCHIVES OF IRANIAN MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.271-276
Keywords: Apoptosis, estrogen, estrogen deficiency, osteoporosis, OSTEOCYTE APOPTOSIS, SKELETAL-MUSCLE, RECEPTOR-ALPHA, MESSENGER-RNA, EXPRESSION, TENDON, BCL-2, FATIGUE, SIGNALS, CELLS
Akdeniz University Affiliated: Yes

Abstract

Background: Estrogen is the major sex steraid affecting the growth, remodeling, and homeostasis Of the-female skeleton. Estrogen loss in postmenopausal women leads to osteoporosis. The aim of this study was to evaluate the early and long- term effects of estrogen loss on bones, tendons, Muscles, and menisci in ovariectomized rats.