Copy For Citation
GUZELOGLU-KAYISLI O., CETIN Z., KESER İ., OZTURK Z., TUNCER T., CANATAN D., ...More
PEDIATRICS INTERNATIONAL, vol.50, no.4, pp.474-476, 2008 (SCI-Expanded)
-
Publication Type:
Article / Article
-
Volume:
50
Issue:
4
-
Publication Date:
2008
-
Doi Number:
10.1111/j.1442-200x.2008.02609.x
-
Journal Name:
PEDIATRICS INTERNATIONAL
-
Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
-
Page Numbers:
pp.474-476
-
Keywords:
beta-thalassemia major, collagen type I A1, osteoporosis, polymerase chain reaction-restriction fragment lengt polymorphism, Sp1 polymorphism, BONE-DENSITY, POSTMENOPAUSAL WOMEN, GENE, FRACTURES, RISK
-
Akdeniz University Affiliated:
Yes
Abstract
Background: beta-Thalassemia is an autosomal recessive disease characterized by defective beta-globin chain production. Osteoporosis is an important cause of morbidity in patients with beta-thalassemia major. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetics factors have been implicated in other populations of patients with osteoporosis. Polymorphism at the Sp1 binding site of the collagen type I A1 (COLIA1) gene is thought to be an important factor in the development of osteoporosis.