Atıf İçin Kopyala
GUZELOGLU-KAYISLI O., CETIN Z., KESER İ., OZTURK Z., TUNCER T., CANATAN D., ...Daha Fazla
PEDIATRICS INTERNATIONAL, cilt.50, sa.4, ss.474-476, 2008 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
50
Sayı:
4
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Basım Tarihi:
2008
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Doi Numarası:
10.1111/j.1442-200x.2008.02609.x
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Dergi Adı:
PEDIATRICS INTERNATIONAL
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.474-476
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Anahtar Kelimeler:
beta-thalassemia major, collagen type I A1, osteoporosis, polymerase chain reaction-restriction fragment lengt polymorphism, Sp1 polymorphism, BONE-DENSITY, POSTMENOPAUSAL WOMEN, GENE, FRACTURES, RISK
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Akdeniz Üniversitesi Adresli:
Evet
Özet
Background: beta-Thalassemia is an autosomal recessive disease characterized by defective beta-globin chain production. Osteoporosis is an important cause of morbidity in patients with beta-thalassemia major. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetics factors have been implicated in other populations of patients with osteoporosis. Polymorphism at the Sp1 binding site of the collagen type I A1 (COLIA1) gene is thought to be an important factor in the development of osteoporosis.