Relationship between SP1 polymorphism and osteoporosis in beta-thalassemia major patients

GUZELOGLU-KAYISLI O., CETIN Z., KESER İ., OZTURK Z., TUNCER T., CANATAN D., ...More

PEDIATRICS INTERNATIONAL, vol.50, no.4, pp.474-476, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1442-200x.2008.02609.x
  • Journal Name: PEDIATRICS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.474-476
  • Keywords: beta-thalassemia major, collagen type I A1, osteoporosis, polymerase chain reaction-restriction fragment lengt polymorphism, Sp1 polymorphism, BONE-DENSITY, POSTMENOPAUSAL WOMEN, GENE, FRACTURES, RISK
  • Akdeniz University Affiliated: Yes

Abstract

Background: beta-Thalassemia is an autosomal recessive disease characterized by defective beta-globin chain production. Osteoporosis is an important cause of morbidity in patients with beta-thalassemia major. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetics factors have been implicated in other populations of patients with osteoporosis. Polymorphism at the Sp1 binding site of the collagen type I A1 (COLIA1) gene is thought to be an important factor in the development of osteoporosis.