Relationship between SP1 polymorphism and osteoporosis in beta-thalassemia major patients
PEDIATRICS INTERNATIONAL, cilt.50, sa.4, ss.474-476, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 4
- Basım Tarihi: 2008
- Doi Numarası: 10.1111/j.1442-200x.2008.02609.x
- Dergi Adı: PEDIATRICS INTERNATIONAL
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.474-476
- Anahtar Kelimeler: beta-thalassemia major, collagen type I A1, osteoporosis, polymerase chain reaction-restriction fragment lengt polymorphism, Sp1 polymorphism, BONE-DENSITY, POSTMENOPAUSAL WOMEN, GENE, FRACTURES, RISK
- Akdeniz Üniversitesi Adresli: Evet
Özet
Background: beta-Thalassemia is an autosomal recessive disease characterized by defective beta-globin chain production. Osteoporosis is an important cause of morbidity in patients with beta-thalassemia major. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetics factors have been implicated in other populations of patients with osteoporosis. Polymorphism at the Sp1 binding site of the collagen type I A1 (COLIA1) gene is thought to be an important factor in the development of osteoporosis.