Hofbauer cells in early human placenta: Possible implications in vasculogenesis and angiogenesis

Seval Y., Korgun E. T., Demir R.

PLACENTA, vol.28, no.8-9, pp.841-845, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 8-9
  • Publication Date: 2007
  • Doi Number: 10.1016/j.placenta.2007.01.010
  • Journal Name: PLACENTA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.841-845
  • Keywords: vasculogenesis, angiogenesis, Hofbauer cells, human placenta, GROWTH-FACTOR, EXPRESSION, VILLI, VEGF
  • Akdeniz University Affiliated: Yes

Abstract

The stroma of the placental villi contain numerous macrophages, so-called Hofbauer cells which are of mesenchymal origin and are thought to function in many processes. Although there are many studies concerning placental vasculogenesis and angiogenesis, there has been a lack of evidence on the possible roles of Hofbauer cells in these processes. In this study we hypothesized that Hofbauer cell locations and numbers might be correlated with the vascular structures within the placental villi core and therefore may be implicated to play roles in placental vasculogenesis and angiogenesis.