Increased Expression of Matrix Metalloproteinase-9 in Patients with Temporal Lobe Epilepsy.

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Acar G., Tanriover G., Acar F., Demir R.

Turkish neurosurgery, vol.25, pp.749-56, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25
  • Publication Date: 2015
  • Doi Number: 10.5137/1019-5149.jtn.10738-14.0
  • Journal Name: Turkish neurosurgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.749-56
  • Keywords: Hippocampal sclerosis, Matrix metalloproteinase-9, Temporal lobe epilepsy, LONG-TERM POTENTIATION, MATRIX METALLOPROTEINASES, SPONTANEOUS SEIZURES, STATUS EPILEPTICUS, RAT-BRAIN, EPILEPTOGENESIS, PLASTICITY, HIPPOCAMPUS, ACTIVATION, CORTEX
  • Akdeniz University Affiliated: Yes

Abstract

AIM:The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited. The aim of this study was to assess the expression of MMP-9, MMP-2 and their tissue inhibitors (TIMP-1 and TIMP-2) in patients with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS).