Increased Expression of Matrix Metalloproteinase-9 in Patients with Temporal Lobe Epilepsy.

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Acar G., Tanriover G., Acar F., Demir R.

Turkish neurosurgery, cilt.25, ss.749-56, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5137/1019-5149.jtn.10738-14.0
  • Dergi Adı: Turkish neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.749-56
  • Anahtar Kelimeler: Hippocampal sclerosis, Matrix metalloproteinase-9, Temporal lobe epilepsy, LONG-TERM POTENTIATION, MATRIX METALLOPROTEINASES, SPONTANEOUS SEIZURES, STATUS EPILEPTICUS, RAT-BRAIN, EPILEPTOGENESIS, PLASTICITY, HIPPOCAMPUS, ACTIVATION, CORTEX
  • Akdeniz Üniversitesi Adresli: Evet

Özet

AIM:The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited. The aim of this study was to assess the expression of MMP-9, MMP-2 and their tissue inhibitors (TIMP-1 and TIMP-2) in patients with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS).