Hemodialysis shortens long in vitro closure times as measured by the PFA-100

Bilgin A. U., Karadogan I., Artac M., Kizilors A., Bilgin R., Undar L.

MEDICAL SCIENCE MONITOR, vol.13, no.3, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2007
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: hemodialysis, platelet, PFA, PLATELET-FUNCTION ANALYZER, PRIMARY HEMOSTASIS, DIALYSIS PATIENTS, FLOW-CYTOMETRY, RENAL-DISEASE, ACTIVATION, UREMIA, ABNORMALITIES, AGGREGOMETRY, AGGREGATION
  • Akdeniz University Affiliated: Yes

Abstract

Background: Hemorrhagic complications are commonly encountered in patients with end-stage renal disease (ESRD). Uremic patients show a bleeding diathesis mainly due to abnormalities in platelet function. There are several tests to detect and measure impairment of hemostasis in these patients, but none appear to be ideal. In recent years, the PFA-100 (platelet function analyzer) was introduced to measure primary, platelet-dependent hemostasis. In this study, the effect of hemodialysis on platelet function was evaluated using the PFA-100 in patients with ESRD.