Development of Crohn's disease following anti-tumour necrosis factor therapy (etanercept)

YAZISIZ V., Avci A. B., Erbasan F., YILDIRIM B., Terzioglu E.

COLORECTAL DISEASE, vol.10, no.9, pp.953-954, 2008 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 10 Issue: 9
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1463-1318.2008.01490.x
  • Journal Name: COLORECTAL DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.953-954
  • Akdeniz University Affiliated: Yes

Abstract

Inhibition of tumour necrosis factor (TNF)-alpha is effective in the treatment of rheumatoid arthritis and other inflammatory rheumatic diseases. Anti-TNF antibodies such as infliximab, etanercept and adalimumab are commonly used. There are structural and functional differences among these agents. We describe development of Crohn's disease in a patient with ankylosing spondylitis receiving anti-TNF therapy. This case suggests that the appearance of gastrointestinal symptoms in patients on anti-TNF therapy must be evaluated to find out whether this is a new onset or an exacerbation of underlying inflammatory bowel disease.

Inhibition of tumour necrosis factor (TNF)-alpha is effective in the treatment of rheumatoid arthritis and other inflammatory rheumatic diseases. Anti-TNF antibodies such as infliximab, etanercept and adalimumab are commonly used. There are structural and functional differences among these agents. We describe development of Crohn's disease in a patient with ankylosing spondylitis receiving anti-TNF therapy. This case suggests that the appearance of gastrointestinal symptoms in patients on anti-TNF therapy must be evaluated to find out whether this is a new onset or an exacerbation of underlying inflammatory bowel disease.