Association of Toll-like receptors 2, 3, and 4 genes polymorphisms with periapical pathosis risk

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Ozan U., Ocak Z., Özan F., Oktay E., Toptaş O., Sahman H., ...Daha Fazla

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, cilt.21, sa.4, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.4317/medoral.21081
  • Dergi Adı: MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Toll-like receptors, periapical pathosis, endodontics, APICAL PERIODONTITIS, DISEASE, TLR4, POPULATION, EXPRESSION, LESIONS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: The aim of this study was to investigate the role of gene variations of Toll-like receptors (TLR) 2, 3, and 4 on genetic susceptibility to periapical pathosis.

Material and methods: One hundred patients were included in the study and divided into two groups as follows; Control Group (n=50) that have root canal treatment and no periapical lesion, Patient Group (n=50) that have root canal treatment and periapical lesion. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Genotypical analysis of control and patient groups were investigated to disclose whether there is any association between periapical lesions and gene variations.

Results: There are no significant statistical differences between control and patient groups according to TLR 2 and 4 gene sequence. On the contrary, CC allele detected 74% for TLR 3 in patient group, and this difference was found to be statistically significant (p < 0.005).

Conclusions: According to these results, it can be suggested that patients with Toll-like receptor 3 gene polymorphisms could be susceptible to periapical pathosis.