A new approach to define dynamics of the ion channel gates

Özer M., Erdem R., Provaznik I.

NEUROREPORT, cilt.15, sa.2, ss.335-338, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1097/00001756-200402090-00025
  • Dergi Adı: NEUROREPORT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.335-338
  • Anahtar Kelimeler: (in)activation gate, ion channel, path probability method, statistical mechanics, EQUILIBRIUM, BEHAVIOR, MODEL
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Voltage-gated ion channels are of great importance in the generation and propagation of electrical signals in the excitable cell membranes. How these channels respond to changes in the potential across the membrane has been a challenging problem, and different approaches have been proposed to address the mechanism of voltage sensing and gating in these channels. In this study, we attempt a new approach by considering a simple two-state gate system and applying the path probability method to construct a nonequilibrium statistical mechanical model of the system. The model which is based on the principles of statistical physics provides a firm physical basis for ion channel gating.