Catechol Biosensor Design Based on Ferrocene-Derivatized 2,5-Dithienyl Pyrrole Copolymer with 3,4-Ethylenedioxythiophene

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Altun A., Apetrei R., Çamurlu P.

Biointerface Research in Applied Chemistry, vol.13, no.1, 2023 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.33263/briac131.037
  • Journal Name: Biointerface Research in Applied Chemistry
  • Keywords: 2,5-di(thienyl)pyrrole, 3,4-ethylenedioxythiophene, carbon nanotubes, catechol sensor, ferrocene, tyrosinase
  • Akdeniz University Affiliated: Yes

Abstract

© 2022 by the authors.Novel conducting platforms based on co(polymerization) of 2,5-dithienyl pyrrole-ferrocene and 3,4-ethylenedioxythiophene were employed for the first time in developing a catechol biosensor. The grafting of Fc moiety onto a hybrid thienyl pyrrole monomer for phenolics detection is proposed for the first time herein to enhance the efficiency of electrochemical reduction of quinone and, in turn, improve the stability of the biosensor in a ‘reagentless’ manner. Tyrosinase enzyme was immobilized by cross-linking onto the carbon nanotubes-enriched electrodeposited films, and catechol was determined with a low detection limit of 2.1 µM. Good operational stability (RSD 3.34 %) was observed during 20 consecutive measurements.