Evaluation of repair process of osteochondral defects in rabbit articular cartilage with an inhibitor of plasminogen activator (tranexamic acid)

Avki S., Hatipoglu F., Yigitarslan K.

REVUE DE MEDECINE VETERINAIRE, vol.154, no.6, pp.421-425, 2003 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 154 Issue: 6
  • Publication Date: 2003
  • Journal Name: REVUE DE MEDECINE VETERINAIRE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.421-425
  • Keywords: tranexamic acid, articular cartilage, osteochondral healing, rabbit, EXOGENOUS FIBRIN CLOT, FIBRONECTIN, INJURY
  • Akdeniz University Affiliated: No

Abstract

To evaluate the effects of an inhibitor of plasminogen activator to hasten the repair of full-thickness articular cartilage defects, 2 mm diameter osteochondral defects were made in 24 adult rabbits and 18 of the rabbits were treated with tranexamic acid intramuscularly every other day for 2 to 4 weeks. The healing response was examined using routine histology at 2, 4 and 12 weeks intervals. Both the experimental (treated with tranexamic acid) and control (nontreated) defects healed through a fibrovascular reparative tissue that finally modulated into fibrocartilage.