Evaluation of repair process of osteochondral defects in rabbit articular cartilage with an inhibitor of plasminogen activator (tranexamic acid)
REVUE DE MEDECINE VETERINAIRE, cilt.154, sa.6, ss.421-425, 2003 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 154 Sayı: 6
- Basım Tarihi: 2003
- Dergi Adı: REVUE DE MEDECINE VETERINAIRE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.421-425
- Anahtar Kelimeler: tranexamic acid, articular cartilage, osteochondral healing, rabbit, EXOGENOUS FIBRIN CLOT, FIBRONECTIN, INJURY
- Akdeniz Üniversitesi Adresli: Hayır
Özet
To evaluate the effects of an inhibitor of plasminogen activator to hasten the repair of full-thickness articular cartilage defects, 2 mm diameter osteochondral defects were made in 24 adult rabbits and 18 of the rabbits were treated with tranexamic acid intramuscularly every other day for 2 to 4 weeks. The healing response was examined using routine histology at 2, 4 and 12 weeks intervals. Both the experimental (treated with tranexamic acid) and control (nontreated) defects healed through a fibrovascular reparative tissue that finally modulated into fibrocartilage.