A Randomized, Open-Label Study of Sirolimus Versus Cyclosporine in Primary De Novo Renal Allograft Recipients

Flechner, Stuart; Gurkan, Alihan; Hartmann, Anders; Legendre, Christophe; Russ, Graeme; Campistol, Josep; Schena, Francesco; Hahn, Carolyn; Li, Huihua; Korth-Bradley, Joan; Tai, Sandi; Schulman, Seth

doi:10.1097/tp.0b013e318291a269

A Randomized, Open-Label Study of Sirolimus Versus Cyclosporine in Primary De Novo Renal Allograft Recipients

Flechner S. M., Gurkan A., Hartmann A., Legendre C. M., Russ G. R., Campistol J. M., ...More

TRANSPLANTATION, vol.95, no.10, pp.1233-1241, 2013 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 95 Issue: 10
Publication Date: 2013
Doi Number: 10.1097/tp.0b013e318291a269
Journal Name: TRANSPLANTATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1233-1241
Keywords: Acute allograft rejection, Delayed graft function, Sirolimus, Cyclosporine, Mycophenolate mofetil, DELAYED GRAFT FUNCTION, KIDNEY-TRANSPLANT RECIPIENTS, CALCINEURIN INHIBITOR DRUGS, MYCOPHENOLATE-MOFETIL, IMMUNOSUPPRESSION REGIMENS, TRIAL, TACROLIMUS, CONVERSION, INDUCTION, EFFICACY
Akdeniz University Affiliated: Yes

Abstract

Background. Despite a decreased incidence of acute rejection and early renal allograft loss due to calcineurin inhibitors (CNIs) in transplant recipients, nephrotoxicity associated with long-term CNI use remains an important issue. This study evaluated whether a CNI-free regimen, including sirolimus, mycophenolate mofetil, corticosteroids, and anti-interleukin-2 receptor antibody induction, results in improved long-term renal function.