A Randomized, Open-Label Study of Sirolimus Versus Cyclosporine in Primary De Novo Renal Allograft Recipients

Flechner, Stuart; Gurkan, Alihan; Hartmann, Anders; Legendre, Christophe; Russ, Graeme; Campistol, Josep; Schena, Francesco; Hahn, Carolyn; Li, Huihua; Korth-Bradley, Joan; Tai, Sandi; Schulman, Seth

doi:10.1097/tp.0b013e318291a269

A Randomized, Open-Label Study of Sirolimus Versus Cyclosporine in Primary De Novo Renal Allograft Recipients

Flechner S. M., Gurkan A., Hartmann A., Legendre C. M., Russ G. R., Campistol J. M., ...Daha Fazla

TRANSPLANTATION, cilt.95, sa.10, ss.1233-1241, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 95 Sayı: 10
Basım Tarihi: 2013
Doi Numarası: 10.1097/tp.0b013e318291a269
Dergi Adı: TRANSPLANTATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1233-1241
Anahtar Kelimeler: Acute allograft rejection, Delayed graft function, Sirolimus, Cyclosporine, Mycophenolate mofetil, DELAYED GRAFT FUNCTION, KIDNEY-TRANSPLANT RECIPIENTS, CALCINEURIN INHIBITOR DRUGS, MYCOPHENOLATE-MOFETIL, IMMUNOSUPPRESSION REGIMENS, TRIAL, TACROLIMUS, CONVERSION, INDUCTION, EFFICACY
Akdeniz Üniversitesi Adresli: Evet

Özet

Background. Despite a decreased incidence of acute rejection and early renal allograft loss due to calcineurin inhibitors (CNIs) in transplant recipients, nephrotoxicity associated with long-term CNI use remains an important issue. This study evaluated whether a CNI-free regimen, including sirolimus, mycophenolate mofetil, corticosteroids, and anti-interleukin-2 receptor antibody induction, results in improved long-term renal function.