Alleviation of prilocaine-induced epileptiform activity and cardiotoxicity by thymoquinone

Akgul B., AYCAN İ. Ö., Hidisoglu E., Afsar E., Yildirim S., TANRIÖVER G., ...More

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, vol.29, no.1, pp.85-99, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1007/s40199-020-00385-2
  • Journal Name: DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.85-99
  • Keywords: Prilocaine, Central nervous system, Cardiovascular, Toxicity, Thymoquinone
  • Akdeniz University Affiliated: Yes

Abstract

Purpose This study investigated whether thymoquinone (TQ) could alleviate central nervous system (CNS) and cardiovascular toxicity of prilocaine, a commonly used local anesthetic.