The Association of Oxidative Stress with Hypertensive Retinopathy

Karaca M., ÇOBAN E., Felek R., ÜNAL M.

CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.35, sa.1, ss.16-19, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/10641963.2012.685535
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.16-19
  • Anahtar Kelimeler: gamma-glutamyl transferase, oxidative stress, hypertension, hypertensive retinopathy, GAMMA-GLUTAMYL-TRANSFERASE, METABOLIC SYNDROME, CARDIOVASCULAR-DISEASE, RISK, DETERMINANTS, PLASMA, LEVEL
  • Akdeniz Üniversitesi Adresli: Evet

Özet

This study was designed to answer the following questions: (i) Do levels of serum gamma-glutamyl transferase (GGT), a marker of oxidative stress, change in hypertensive retinopathy (HR)? (ii) Is there any relation between degree of HR and GGT levels? This study included 80 hypertensive patients with HR. Group 1 comprised 40 patients with grade I HR, and group 2 comprised 40 patients with grade II HR. We selected 40 healthy subjects for the control group. Level of GGT in group 2 was significantly higher than in group 1 (P = 0.005) and control group (P = 0.001); it was also higher in group 1 than in control group (P = 0.025). Our study suggests that oxidative stress, mechanisms known to be involved in vascular lesions, may promote the development of HR.