The effects of short-term nifedipine treatment on responsiveness of aortic rings of cadmium-hypertensive rats


Ozdem S. S., OGUTMAN C.

CLINICAL AND EXPERIMENTAL HYPERTENSION, vol.21, no.4, pp.423-440, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 1999
  • Doi Number: 10.3109/10641969909068674
  • Journal Name: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.423-440
  • Keywords: cadmium, hypertension, nifedipine, rat, VASCULAR REACTIVITY, CALCIUM-ANTAGONISTS, ENDOTHELIN-1, FELODIPINE, RESPONSES, COMBINATION, MECHANISMS, RECEPTORS
  • Akdeniz University Affiliated: Yes

Abstract

The effects of short-term antihypertensive treatment with nifedipine on blood pressure and vascular responsiveness were studied in cadmium-hypertensive and normotensive control rats. Cadmium administration caused a significant increase in mean arterial blood pressure. Endothelin-1, noradrenaline and angiotensin II produced concentration dependent contractions of aortic rings that attained a lower maximal contraction in cadmium-hypertensive rats. Responses of aortic rings to KCl did not show a significant difference between the groups. Nifedipine administered simultaneously with cadmium inhibited the induction of hypertension. Nifedipine treatment for 5 days significantly reduced the blood pressure in cadmium-hypertensive and normotensive rats. Neither inhibition of hypertension nor normalization of blood pressure in cadmium-hypertensive rats caused an alteration in contractile responses of aortic rings to vasoconstrictors which suggested that development of decreased vascular reactivity and of hypertension occurs simultaneously in cadmium-hypertensive rats but the role of decreased vascular reactivity in maintenance of hypertension is questionable in cadmium-hypertension.