The effects of non-surgical periodontal therapy on neutrophil elastase and elastase alpha-1 proteinase inhibitor levels in GCF in periodontitis patients with or without acute coronary syndrome

KAYAR N. A., ÜSTÜN K., Gozlu M., Haliloglu S., Alptekin N. O.

CLINICAL ORAL INVESTIGATIONS, vol.25, no.5, pp.3329-3338, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.1007/s00784-021-03838-3
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.3329-3338
  • Keywords: Non-surgical periodontal therapy, Acute coronary syndrome, Neutrophil elastase, Alpha-1 proteinase inhibitor
  • Akdeniz University Affiliated: Yes


Objective Periodontitis may contribute to vascular damage, resulting in the destabilization of atherosclerotic plaque leading to acute coronary syndrome (ACS). In this study, we explored the effect of non-surgical periodontal treatment (NSPT) on cardiovascular blood biomarkers and gingival crevicular fluid (GCF) neutrophil elastase (NE) and alpha 1-proteinase inhibitor (alpha-1PI) levels in periodontitis (P) participants with and without ACS.