Effects of intrathecal administration of FK506 after sciatic nerve crush injury

SARIKCIOĞLU L., Duygulu E., Aydin H., GÜRER İ. E., ÖZKAN Ö., Tuzuner S.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY, vol.22, no.8, pp.649-654, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 8
  • Publication Date: 2006
  • Doi Number: 10.1055/s-2006-956239
  • Journal Name: JOURNAL OF RECONSTRUCTIVE MICROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.649-654
  • Keywords: FK506, sciatic nerve crush, recovery, intrathecal administration, SPINAL-CORD-INJURY, GROWTH-FACTOR-I, SACCHAROMYCES-CEREVISIAE, AXONAL REGENERATION, FUNCTIONAL RECOVERY, RAT, CATHETERIZATION, INCREASES, EXPRESSION, ORG-2766
  • Akdeniz University Affiliated: Yes

Abstract

Although various administration routes of FK506 have been published, intrathecal administration of FK506 has not previously been reported in the literature. A daily dose of 0.05 mg/kg of FK506 was given (a small dose compared with those reported in the available literature). The authors used this small dose to obtain lower immunosuppression and neurotoxicity, and a higher axonal regeneration rate.