Effects of intrathecal administration of FK506 after sciatic nerve crush injury
JOURNAL OF RECONSTRUCTIVE MICROSURGERY, cilt.22, sa.8, ss.649-654, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 8
- Basım Tarihi: 2006
- Doi Numarası: 10.1055/s-2006-956239
- Dergi Adı: JOURNAL OF RECONSTRUCTIVE MICROSURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.649-654
- Anahtar Kelimeler: FK506, sciatic nerve crush, recovery, intrathecal administration, SPINAL-CORD-INJURY, GROWTH-FACTOR-I, SACCHAROMYCES-CEREVISIAE, AXONAL REGENERATION, FUNCTIONAL RECOVERY, RAT, CATHETERIZATION, INCREASES, EXPRESSION, ORG-2766
- Akdeniz Üniversitesi Adresli: Evet
Özet
Although various administration routes of FK506 have been published, intrathecal administration of FK506 has not previously been reported in the literature. A daily dose of 0.05 mg/kg of FK506 was given (a small dose compared with those reported in the available literature). The authors used this small dose to obtain lower immunosuppression and neurotoxicity, and a higher axonal regeneration rate.