Thrombotic thrombocytopenic purpura: A single - Centre experience


Yildirim R., Bilen Y., Keles M., UYANIK A., ALBAYRAK F., ERDEM F., ...More

TRANSFUSION AND APHERESIS SCIENCE, vol.43, no.2, pp.159-162, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1016/j.transci.2010.07.007
  • Journal Name: TRANSFUSION AND APHERESIS SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.159-162
  • Keywords: Thrombotic thrombocytopenic purpura, Total plasma exchange, Organ damage, Mortality, VON-WILLEBRAND-FACTOR, FACTOR-CLEAVING PROTEASE, PLASMA-EXCHANGE, ADAMTS13, AUTOANTIBODIES
  • Akdeniz University Affiliated: No

Abstract

We aimed to describe the characteristics, treatment regime, and 6-month all-cause mortality of thrombotic thrombocytopenic purpura (TTP) patients treated with total plasma exchange in the our clinic. Thirteen patients were included in the study. Mortality rates of TTP have improved over the last three decades but they are still too high according to modern therapy expectations. Etiology directed treatment should be added to total plasma exchange in secondary TTP cases. Based on TTPs' immunologic etiology, immune modulator and immune suppressor agents have been applied together with total plasma exchange, but mostly in anecdotal case reports or with questionable responses. (C) 2010 Elsevier Ltd. All rights reserved.