EARLY AND CONTINUED MANUAL STIMULATION IS REQUIRED FOR LONG-TERM RECOVERY AFTER FACIAL NERVE INJURY

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Grosheva M., Rink S., Jansen R., Bendella H., Pavlov S. P., SARIKCIOĞLU L., ...Daha Fazla

MUSCLE & NERVE, cilt.57, sa.1, ss.100-106, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1002/mus.25613
  • Dergi Adı: MUSCLE & NERVE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.100-106
  • Anahtar Kelimeler: facial nerve, manual stimulation, recovery, surgical reconstruction, timing, FIBER-TYPE DISPROPORTION, CONGENITAL MYOPATHY, TPM2 GENE, MUTATIONS, TROPOMYOSIN, PHENOTYPE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction: We previously have shown that manual stimulation (MS) of vibrissal muscles for 2 months after facial nerve injury in rats improves whisking and reduces motor end plate polyinnervation. Here, we seek to determine whether discontinuing or delaying MS after facial-facial anastomosis (FFA) leads to similar results. Methods: Rats were subjected to FFA and received MS for (1) 4 months (early and continued), (2) the first but not the last 2 months (discontinued), or (3) the last 2 months (delayed). Intact animals and those not receiving MS (no MS) were also examined. Results: Early and continued MS restored whisking amplitude to 438, a value significantly higher compared with the discontinued, delayed, and no MS groups (328, 248, and 108, respectively). Motor end plate polyinnervation occurred in all experimental groups but was significantly higher in the delayed group. Discussion: Early and continued MS results in better recovery than when it is either discontinued or delayed.