Association of Serum Homocysteine and Methionine Levels with Cognition and Functioning in Bipolar Disorder

BAYSAL G. Ö., GOEKMEN Z., AKBAS H., CİNEMRE B., METIN O., Karaman T.

TURK PSIKIYATRI DERGISI, vol.24, no.1, pp.7-16, 2013 (SSCI) identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5080/u6881
  • Journal Name: TURK PSIKIYATRI DERGISI
  • Journal Indexes: Social Sciences Citation Index (SSCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.7-16
  • Keywords: Bipolar disorder, homocysteine, methionine, cognitive functions, LIFE-STYLE, SCHIZOPHRENIC-PATIENTS, PLASMA HOMOCYSTEINE, RATING-SCALE, DEPRESSION, FOLATE, DETERMINANTS, EPIGENETICS, METABOLISM, SYMPTOMS
  • Akdeniz University Affiliated: Yes

Abstract

Objective: The relationship between homocysteine (HCY) levels and cognitive impairments, particularly executive functions in bipolar disorder (BD), has recently been investigated. However, conflicting results were reported. The aim of the present study is to investigate changes in serum HCY, methionine, vitamine B12 and levels in BD patients are relative to controls and to investigate the relationship between HCY, methionine, vitamin B12, and folate levels and clinical features, cognitive functions and psychosocial functioning in euthymic BD patients and controls.