Total Antioxidant Capacity, Hydrogen Peroxide, Malondialdehyde and Total Nitric Oxide Concentrations in Patients with Severe Persistent Allergic Asthma: Its Relation To Omalizumab Treatment

Yalcin A. D., Gorczynski R. M., Parlak G. E., Kargi A., Bisgin A., Sahin E., ...More

CLINICAL LABORATORY, vol.58, no.1-2, pp.89-96, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 1-2
  • Publication Date: 2012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.89-96
  • Keywords: Omalizumab, allergic asthma, antioxidant, hydrogen peroxide, malondialdehyde, nitric oxide, ANTI-IGE ANTIBODY, IMMUNOTHERAPY, RHINITIS, STRESS, ANAPHYLAXIS, ENDOTHELIN, EFFICACY, MODELS
  • Akdeniz University Affiliated: Yes


Background: Asthma is a chronic inflammatory disease and omalizumab is indicated for moderate-to-severe persistent asthma. The results of many studies have shown that oxidative stress is involved in asthma pathogenesis. However, there is no data available to evaluate the alterations in total antioxidant capacity, hydrogen peroxide, malondialdehyde, and total nitric oxide concentrations.