Dynamic changes of histone methylation in mammalian oocytes and early embryos

Bilmez Y., Talibova G., ÖZTÜRK S.

HISTOCHEMISTRY AND CELL BIOLOGY, cilt.157, sa.1, ss.7-25, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 157 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s00418-021-02036-2
  • Dergi Adı: HISTOCHEMISTRY AND CELL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.7-25
  • Anahtar Kelimeler: Histone methylation, Histone methyltransferase, Histone demethylation, Oocyte, Early embryo, Gene expression
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Histone methylation is a key epigenetic mechanism and plays a major role in regulating gene expression during oocyte maturation and early embryogenesis. This mechanism can be briefly defined as the process by which methyl groups are transferred to lysine and arginine residues of histone tails extending from nucleosomes. While methylation of the lysine residues is catalyzed by histone lysine methyltransferases (KMTs), protein arginine methyltransferases (PRMTs) add methyl groups to the arginine residues. When necessary, the added methyl groups can be reversibly removed by histone demethylases (HDMs) by a process called histone demethylation. The spatiotemporal regulation of methylation and demethylation in histones contributes to modulating the expression of genes required for proper oocyte maturation and early embryonic development. In this review, we comprehensively evaluate and discuss the functional importance of dynamic histone methylation in mammalian oocytes and early embryos, regulated by KMTs, PRMTs, and HDMs.