Effects of long- and short-term darbepoetin-alpha treatment on oxidative stress, inflammation and endothelial injury in ApoE knockout mice

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OZDEMIR E. D., Hanikoglu A., Cort A., ÖZBEN SADIÇ B., SÜLEYMANLAR G., Ozben T.

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, vol.26, no.4, pp.635-643, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.17219/acem/62834
  • Journal Name: ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.635-643
  • Keywords: oxidative stress, atherosclerosis, endothelial dysfunction, darbepoetin-alpha, ApoE knockout mice, E-DEFICIENT MICE, ATHEROSCLEROTIC LESIONS, APOLIPOPROTEIN, HYPERCHOLESTEROLEMIA, INTERLEUKIN-6, EXPRESSION, HISTAMINE, FAILURE, RELEASE
  • Akdeniz University Affiliated: Yes

Abstract

Background. Atherosclerosis and atherosclerosis-related complications are the main cause of death in the world. Vascular injury in response to inflammation and enhanced oxidant stress promotes endothelial dysfunction and leads to atherosclerotic lesions.