The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies
ARCHIVES OF DERMATOLOGICAL RESEARCH, vol.307, no.7, pp.551-557, 2015 (SCI-Expanded, Scopus)
- Publication Type: Article / Review
- Volume: 307 Issue: 7
- Publication Date: 2015
- Doi Number: 10.1007/s00403-015-1546-2
- Journal Name: ARCHIVES OF DERMATOLOGICAL RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.551-557
- Keywords: Growth Differentiation Factor-15, GDF-15, MIC-1, Systemic sclerosis, Melanoma, Senescence, MACROPHAGE INHIBITORY CYTOKINE-1, TGF-BETA SUPERFAMILY, BONE MORPHOGENETIC PROTEINS, HUMAN DERMAL FIBROBLASTS, MOUSE MELANOMA-CELLS, SYSTEMIC-SCLEROSIS, GENE-EXPRESSION, CANCER CELLS, CUTANEOUS MELANOMA, MIC-1
- Akdeniz University Affiliated: Yes
Abstract
GDF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor beta (TGF-beta) superfamily. GDF-15 is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses, bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15, which is regulated by p53, has shown antitumorigenic and proapoptotic activities in vivo and in vitro. Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin fibrosis and malignant lesions of the skin.