Correlation of Metabolic Syndrome with Serum BDNF, Vitamin B12 And Folate In Schizophrenic Patients

Kulaksizoglu B., Kulaksizoglu S.

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, cilt.7, sa.6, ss.3142-3151, 2016 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 6
  • Basım Tarihi: 2016
  • Dergi Adı: RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE
  • Sayfa Sayıları: ss.3142-3151
  • Anahtar Kelimeler: Schizophrenia, Metabolic syndrome, BDNF, PANSS, vitamin B12, folate, INSULIN-RESISTANCE, PSYCHOPATHOLOGY, HOMOCYSTEINE, EXPRESSION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The aim of this study is to evaluate the correlation of vitamin B12, folate and serum (brain derived neurotrophic factor) BDNF levels with anthropometric ((body mass index (BMI) and waist circumference), metabolic (glucose, insulin, insulin resistance, HbA1c and lipid profile) and psychopathological (positive and negative syndrome scale (PANSS)) parameters. Anthropometrical parameters (weight, height, BMI and waist circumference), systolic and diastolic blood pressure, serum glucose, HDL, LDL, triglyceride, total cholesterol, HbA1c, insulin, vitamin B12, folate, HOMA-IR and serum BDNF values of 64 schizophrenic patients and 54 healthy individuals, whose informed consent was obtained, and were measured using the sandwich ELISA (enzyme-linked immune sorbent assay) method. The PANSS was used to evaluate the patients. Serum BDNF and vitamin B12 levels were found to be significantly lower in 27 (42.18%) schizophrenic patients with the diagnosis of metabolic syndrome (MetS) when compared to the other schizophrenic patients (p < 0.001 and p=0.012, respectively). Significant negative correlations were found among BDNF, folate and vitamin B12 (r=0.651, p < 0.001; r= -0.324, p=0.009; r= -0.646, p < 0.001, respectively) with PANSS-negative syndrome scale, between BDNF and vitamin B12 (r= -0.523, p < 0.001; r= -0.313, p=0.012, respectively) with PANSS-positive syndrome score and between BDNF and vitamin B12 (r= -0.381, p=0.002; r= -0.268, p=0.032, respectively) with PANSS-total syndrome scalee. In patients with schizophrenia, vitamin B12 level and BDNF were found to be positively correlated. Lower serum BDNF and vitamin B12 levels in schizophrenic patients may be correlated with a risk of the development of MetS and increased psychotic symptoms. In addition, folate deficiency may be associated with a higher PANSS-negative syndrome scale, especially in schizophrenic patients. Psychotic symptoms might be more intense in schizophrenic patients with MetS compared to schizophrenic patients without MetS