Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report

Dirican E. K., Isik A., Vicdan K., Sozen E., Suludere Z.

ASIAN JOURNAL OF ANDROLOGY, vol.10, no.2, pp.332-336, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1745-7262.2008.00248.x
  • Journal Name: ASIAN JOURNAL OF ANDROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.332-336
  • Keywords: intracytoplasmic sperm injection, spermatozoa, acrosome, scanning electron microscopy, SPERM INJECTION, FAILURE
  • Akdeniz University Affiliated: No

Abstract

We report the successful outcome of intracytoplasmic sperm injection ( ICSI) treatment in two siblings with familial globozoospermia. After controlled ovarian
hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second
couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo
in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate,
and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy.
We report the successful outcome of intracytoplasmic sperm injection ( ICSI) treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy.