Oxidative Stress and the Cardiovascular System

Yesilkaya A.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.28, sa.6, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2008
  • Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Oxidative stres, cardiovascular system, LIPID-PEROXIDATION, OXYGEN, PEROXYNITRITE, DISEASE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Reactive oxygen species (ROS) influence many physiological processes in the human body and under normal conditions the rate and magnitude of oxidant formation is balanced by antioxidants. Under pathalogical conditions ROS play an important role in renal and cardiovascular dysfunction. These ROS can be released from NADPH oxidase, xanthine oxidase, lipoxygenase, or nitric oxide synthase in vascular cells. There are growing evidences that the oxidative stress hypthesis effect atherosclerosis. ROS can modulate vascular function either by direct oxidative damage or by activating cellular signaling pathways that lead to abnormal contractile, imflamatory, proliferative, or remodeling properties of the blood vessel. Here we focused on the ROS mechanisms that effect the vasculature.