Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout

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Aksakal E., CEYHUN S. B., ERDOĞAN O., Ekinci D.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, cilt.152, sa.4, ss.451-455, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.cbpc.2010.07.004
  • Dergi Adı: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.451-455
  • Anahtar Kelimeler: Deltamethrin, Growth hormone, Muscles, Insulin like growth factors, Oncorhynchus mykiss, Gene expression, Real-time PCR, FRESH-WATER FISH, II IGF-II, IN-VITRO, AUTOCRINE PARACRINE, OXIDATIVE STRESS, GENE-EXPRESSION, DNA-DAMAGE, RECEPTOR, FORMS, AXIS
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

We report here the acute and long-term influences of deltamethrin on the expression of IGF-I, IGF-II and GH-I in rainbow trout muscles. We treated rainbow trouts with different concentrations of deltamethrin (0.25 mu g/L, 1 mu g/L and 2.5 mu g/L) and observed the alterations in mRNA expression levels of IGF-I, IGF-II and GH-I at different time intervals (at 6th, 12th, 24th, 48th, 72nd hours and 30th day). The mRNA levels significantly decreased with increasing deltamethrin concentrations for acute administration. Interestingly, a significant recovery in GH-I expression was seen after the 72nd hour up to 30th day while no significant differences were observed for IGF-I and IGF-II between the same time intervals. Here we demonstrate that deltamethrin exposure decreases the expression of IGF-I. IGF-II and GH-I in rainbow trout which might cause undesirable outcomes not only in growth, but also in development and reproduction. (C) 2010 Elsevier Inc. All rights reserved.