Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome

Kucuksayan E., Ozben S., Tuac S. T., Koseoglu M., EREL Ö., NEŞELİOĞLU S., ...More

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.59, no.7, pp.1257-1265, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1515/cclm-2020-1659
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1257-1265
  • Keywords: disulphide, native thiol, oxidative stress, restless legs syndrome, thiol disulphide homeostasis, total thiol, THIOL-DISULFIDE HOMEOSTASIS, OXIDATIVE STRESS MARKER, REACTIVE OXYGEN, NITRIC-OXIDE, DISEASE, GLUTATHIONE, INHIBITION, IMPAIRMENT, APOPTOSIS
  • Akdeniz University Affiliated: Yes


Objectives: Restless legs syndrome (RLS) is a common neurological condition. Oxidative stress plays an important role in its pathogenesis. Thiol-disulphide homeostasis (TDH) is a new biomarker of oxidative stress. We studied plasma TDH to determine whether TDH could be used as a new biomarker for RLS and evaluated correlations between TDH and various disease severity rating scales.