Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.59, no.7, pp.1257-1265, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 59 Issue: 7
- Publication Date: 2021
- Doi Number: 10.1515/cclm-2020-1659
- Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
- Page Numbers: pp.1257-1265
- Keywords: disulphide, native thiol, oxidative stress, restless legs syndrome, thiol disulphide homeostasis, total thiol, THIOL-DISULFIDE HOMEOSTASIS, OXIDATIVE STRESS MARKER, REACTIVE OXYGEN, NITRIC-OXIDE, DISEASE, GLUTATHIONE, INHIBITION, IMPAIRMENT, APOPTOSIS
- Akdeniz University Affiliated: Yes
Abstract
Objectives: Restless legs syndrome (RLS) is a common neurological condition. Oxidative stress plays an important role in its pathogenesis. Thiol-disulphide homeostasis (TDH) is a new biomarker of oxidative stress. We studied plasma TDH to determine whether TDH could be used as a new biomarker for RLS and evaluated correlations between TDH and various disease severity rating scales.