Synthesis, characterization and anti-proliferative activity of Cd(II) complexes with NNN type pyrazole-based ligand and pseudohalide ligands as coligand

Hopa C., Yildirim H., Kara H., Kurtaran R., Alkan M.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol.121, pp.282-287, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121
  • Publication Date: 2014
  • Doi Number: 10.1016/j.saa.2013.10.028
  • Journal Name: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.282-287
  • Keywords: Pyrazole-pyridine ligand, Cadmium(II), X-ray structure, Nitrite, Dicyanamide, Cytotoxicity, CELL-LINE, CADMIUM, OSTEOSARCOMA, EXPRESSION, CRYSTAL, SPECTROSCOPY, SURVIVAL, HYPOXIA, DEATH
  • Akdeniz University Affiliated: Yes

Abstract

Cd(II) complexes of tridentate nitrogen donor ligand, 2,6-bis(3,4,5-trimethylpyrazolyl)pyridine (btmpp), Cd(btmpp)X-2 (X:Cl, ONO or N(CN)(2)) have been synthesized and characterized by elemental and spectral (FT-IR, H-1 NMR, C-13 NMR, UV-Vis) analyses, differential thermal analysis and single crystal X-ray diffraction studies. The molecular structure of reported complex 1, revealed distorted square-pyramidal geometry around Cadmium. Complexes 1-3 and corresponding ligand were tested for cytotoxic activity against the human carcinoma cell lines HEP3B (hepatocellular carcinoma), PC3 (prostate adenocarcinoma), MCF7 (breast adenocarcinoma) and Saos2 (osteosarcoma). The results show that, complexes are more cytotoxic than the free ligand and complex 2 is the most cytotoxic complex for PC3. (C) 2014 Published by Elsevier B.V.