Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta.

Soygur B., Sati L., Demir R.

Histology and histopathology, cilt.31, ss.1037-47, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31
  • Basım Tarihi: 2016
  • Doi Numarası: 10.14670/hh-11-735
  • Dergi Adı: Histology and histopathology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1037-47
  • Anahtar Kelimeler: Syncytin, SLC1A5, MFSD2, Human placenta, Gestational diabetes, HERV-W, EXTRAVILLOUS TROPHOBLAST, MICROVILLOUS MEMBRANE, CHORIONIC VILLI, GLYCOPROTEIN, PREGNANCY, EXOSOMES, SYNCYTIOTROPHOBLAST, LOCALIZATION, PATHOLOGY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction: Syncytins belong to the Human Endogenous Retrovirus family. The syncytin-1 receptor, SLC1A5, and syncytin-2 receptor, MFSD2, interact with their respective syncytin proteins to induce syncytiotrophoblast formation. However, there is no information about syncytins in gestational diabetic placenta. Therefore, we studied the expression and localization of syncytins and their receptors during normal placental development and in gestational diabetic placenta.