Altered expression of human endogenous retroviruses syncytin-1, syncytin-2 and their receptors in human normal and gestational diabetic placenta.
Histology and histopathology, vol.31, pp.1037-47, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 31
- Publication Date: 2016
- Doi Number: 10.14670/hh-11-735
- Journal Name: Histology and histopathology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1037-47
- Keywords: Syncytin, SLC1A5, MFSD2, Human placenta, Gestational diabetes, HERV-W, EXTRAVILLOUS TROPHOBLAST, MICROVILLOUS MEMBRANE, CHORIONIC VILLI, GLYCOPROTEIN, PREGNANCY, EXOSOMES, SYNCYTIOTROPHOBLAST, LOCALIZATION, PATHOLOGY
- Akdeniz University Affiliated: Yes
Abstract
Introduction: Syncytins belong to the Human Endogenous Retrovirus family. The syncytin-1 receptor, SLC1A5, and syncytin-2 receptor, MFSD2, interact with their respective syncytin proteins to induce syncytiotrophoblast formation. However, there is no information about syncytins in gestational diabetic placenta. Therefore, we studied the expression and localization of syncytins and their receptors during normal placental development and in gestational diabetic placenta.