Loss of tight junction proteins (Claudin 1, 4, and 7) correlates with aggressive behavior in colorectal carcinoma

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Suren D., Yildirim M., KAYA V., Alikanoglu A. S., Bulbuller N., Yildiz M., ...More

MEDICAL SCIENCE MONITOR, vol.20, pp.1255-1262, 2014 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 20
  • Publication Date: 2014
  • Doi Number: 10.12659/msm.890598
  • Journal Name: MEDICAL SCIENCE MONITOR
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1255-1262
  • Keywords: Claudin 1, Claudin 4, Claudin 7, Colorectal Neoplasms, Prognosis, Tight Junctions, REDUCED EXPRESSION, COLONIC-CANCER, INVASION, PROGRESSION, METASTASIS, MIGRATION, PROMOTES, MARKER, LIVER
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

Background: Tight junction proteins in the cell organize paracellular permeability and they play a critical role in apical cell-to-cell adhesion and epithelial polarity. Claudins are major integral membrane proteins of tight junctions, especially Claudin 1, 4, and 7, which are known as the impermeability Claudins. In this study, we investigated the importance of loss of Claudin 1, 4, and 7 expression, and their relation to tumor progression in colorectal cancer patients.