Loss of tight junction proteins (Claudin 1, 4, and 7) correlates with aggressive behavior in colorectal carcinoma

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Suren D., Yildirim M., KAYA V., Alikanoglu A. S., Bulbuller N., Yildiz M., ...Daha Fazla

MEDICAL SCIENCE MONITOR, cilt.20, ss.1255-1262, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2014
  • Doi Numarası: 10.12659/msm.890598
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1255-1262
  • Anahtar Kelimeler: Claudin 1, Claudin 4, Claudin 7, Colorectal Neoplasms, Prognosis, Tight Junctions, REDUCED EXPRESSION, COLONIC-CANCER, INVASION, PROGRESSION, METASTASIS, MIGRATION, PROMOTES, MARKER, LIVER
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Tight junction proteins in the cell organize paracellular permeability and they play a critical role in apical cell-to-cell adhesion and epithelial polarity. Claudins are major integral membrane proteins of tight junctions, especially Claudin 1, 4, and 7, which are known as the impermeability Claudins. In this study, we investigated the importance of loss of Claudin 1, 4, and 7 expression, and their relation to tumor progression in colorectal cancer patients.