COVID-19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene prevalence


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Ponti G., Pastorino L., Manfredini M., Ozben T., Oliva G., Kaleci S., ...More

JOURNAL OF CLINICAL LABORATORY ANALYSIS, vol.35, no.7, 2021 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 35 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1002/jcla.23798
  • Journal Name: JOURNAL OF CLINICAL LABORATORY ANALYSIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Analytical Abstracts, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: C677 T mutation prevalence, COVID-19 vulnerability, Homocysteine, MTHFR gene, HYPERHOMOCYSTEINEMIA, HOMOCYSTEINE, FREQUENCIES
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

Background: Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR C677 T gene polymorphism and COVID-19 incidence and mortality worldwide.