Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial

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Bluth T., Teichmann R., Kiss T., Bobek I., Canet J., Cinnella G., ...More

TRIALS, vol.18, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18
  • Publication Date: 2017
  • Doi Number: 10.1186/s13063-017-1929-0
  • Journal Name: TRIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Mechanical ventilation, Positive end-expiratory pressure, Recruitment maneuver, Obesity, Postoperative pulmonary complication, POSTOPERATIVE PULMONARY COMPLICATIONS, ALVEOLAR RECRUITMENT MANEUVER, RESPIRATORY-DISTRESS-SYNDROME, MECHANICAL VENTILATION, GENERAL-ANESTHESIA, DRIVING PRESSURE, TIDAL VOLUMES, INTERNATIONAL CONSENSUS, LIVER-FAILURE, LUNG-VOLUMES
  • Akdeniz University Affiliated: No

Abstract

Background: Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients.