Akademik Veri Yönetim Sistemi
Journal of Herbal Medicine, cilt.54, 2025 (SCI-Expanded, Scopus)
Antimicrobial resistance (AMR) poses a severe and escalating global health crisis, directly contributing to increased morbidity, mortality, and healthcare costs due to fewer effective infection treatment options. Due to their wealth of bioactives, secondary metabolites, and natural products with antimicrobial properties, plants and fungi are considered some of the most promising yet underexplored candidates in the search for novel therapeutic strategies with compounds providing diverse mechanisms of action. Plant-derived compounds, such as alkaloids, flavonoids, and terpenoids, or fungal-derived bioactives such as polyketides, peptides, and oligo and polysaccharides, have demonstrated promising antimicrobial activity against multidrug-resistant bacteria and fungi. The multitargeting mechanisms of action employed by these compounds can further improve their efficacy against antimicrobial-resistant pathogens. In this review, the main AMR strategies utilised by multidrug-resistant bacteria have been narratively detailed, and the potential of nature-based (plants and fungi) antimicrobial compounds, particularly with a focus on their effectiveness against resistance strategies with regard to the latest advancements, have been critically reviewed and addressed. The gaps in current knowledge, particularly regarding the real-world applications of natural antimicrobials, have also been identified. This will facilitate further understanding of plant and fungi-derived antimicrobials and highlight their therapeutic potential in overcoming the global AMR crisis.