The role of apelin in the healing of water-immersion and restraint stress-induced gastric damage

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Birsen I., Gemici B., Acar N., Üstünel İ., Uysal V. N.

JOURNAL OF PHYSIOLOGICAL SCIENCES, cilt.67, sa.3, ss.373-385, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s12576-016-0469-9
  • Dergi Adı: JOURNAL OF PHYSIOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.373-385
  • Anahtar Kelimeler: Apelin, F13A, Gastric mucosa, Lesion, Water immersion and restraint stress, NITRIC-OXIDE SYNTHASE, LIPID-PEROXIDATION, CELL-PROLIFERATION, OXIDATIVE STRESS, SENSORY NERVES, EXPRESSION, PROTECTION, APJ, PROSTAGLANDINS, ANGIOGENESIS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The objective of this study was to explore the role of apelin in the healing of gastric lesions induced by stress. Male Wistar rats were exposed to water immersion and restraint stress (WIRS) for 6 h with or without the apelin receptor antagonist F13A. The rats were killed on the 1st, 3rd, 5th or 10th day after the end of stress induction. Apelin and hypoxia-inducible factor-1 alpha expression was increased on the 1st day after the end of stress exposure and was decreased daily thereafter. However, F13A retarded the healing of gastric lesions by preventing the improvement of mucosal blood flow, prostaglandin E-2 production and vascular endothelial growth factor expression in rats exposed to WIRS. Additionally, F13A increased the gastric 4-hydroxynonenol + malondialdehyde content on the 1st and 3rd days after the end of stress induction but did not affect the change in gastric mucosal nitric oxide levels. In conclusion, apelin may be a regulatory protein involved in the healing mechanism of stress-induced gastric damage.