KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes and pyramidal cells of the adult human cerebral cortex
NEUROSURGERY, cilt.54, sa.4, ss.943-949, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 54 Sayı: 4
- Basım Tarihi: 2004
- Doi Numarası: 10.1227/01.neu.0000114512.59624.a5
- Dergi Adı: NEUROSURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.943-949
- Anahtar Kelimeler: astrocytes, blood-brain barrier, cerebral cavernous malformation endothelium, KRIT1, BLOOD-BRAIN-BARRIER, EXPRESSION ANALYSIS, BINDING-PROTEIN, ENCODING KRIT1, GENE, MUTATIONS, CCM1, MORPHOGENESIS, PATHOGENESIS, ASSOCIATION
- Akdeniz Üniversitesi Adresli: Hayır
Özet
OBJECTIVE:, Mutations in KRIT1 cause familial cerebral cavernous malformation, an autosomal dominant disorder affecting primarily the central nervous system vasculature. . Although recent studies have suggested that Krev-1 interaction trapped 1(KRIT1) is a microtubule-associated protein that interacts with integrin cytoplasmic domain- associated protein-1alpha, the function of KRIT1 remains elusive.