KRIT1/cerebral cavernous malformation 1 protein localizes to vascular endothelium, astrocytes and pyramidal cells of the adult human cerebral cortex

Guzeloglu-Kayisli O., Amankulor N., Voorhees J., Luleci G., Lifton R., Gunel M.

NEUROSURGERY, vol.54, no.4, pp.943-949, 2004 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 54 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1227/01.neu.0000114512.59624.a5
  • Journal Name: NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.943-949
  • Keywords: astrocytes, blood-brain barrier, cerebral cavernous malformation endothelium, KRIT1, BLOOD-BRAIN-BARRIER, EXPRESSION ANALYSIS, BINDING-PROTEIN, ENCODING KRIT1, GENE, MUTATIONS, CCM1, MORPHOGENESIS, PATHOGENESIS, ASSOCIATION
  • Akdeniz University Affiliated: No

Abstract

OBJECTIVE:, Mutations in KRIT1 cause familial cerebral cavernous malformation, an autosomal dominant disorder affecting primarily the central nervous system vasculature. . Although recent studies have suggested that Krev-1 interaction trapped 1(KRIT1) is a microtubule-associated protein that interacts with integrin cytoplasmic domain- associated protein-1alpha, the function of KRIT1 remains elusive.