NEUROSURGERY, vol.54, no.4, pp.943-949, 2004 (SCI-Expanded)
OBJECTIVE:, Mutations in KRIT1 cause familial cerebral cavernous malformation, an autosomal dominant disorder affecting primarily the central nervous system vasculature. . Although recent studies have suggested that Krev-1 interaction trapped 1(KRIT1) is a microtubule-associated protein that interacts with integrin cytoplasmic domain- associated protein-1alpha, the function of KRIT1 remains elusive.